Outcomes, Earlier than and After Photos, Dosages

What’s RAD 140?

RAD 140, or testolone, is a non-steroidal SARM (selective androgen receptor modulator) that replicates the anabolic results of steroids by binding to the androgen receptor.

RAD 140 and different SARMs had been formulated to offer extra optimum therapy for sufferers affected by osteoporosis, cachexia, and anemia. Nevertheless, RAD 140 has not but been confirmed to be protected clinically.

Though anabolic steroids produce vital will increase in lean mass, additionally they induce detrimental cardiovascular, hepatic, estrogenic, and androgenic unwanted effects. Thus, by way of the mechanism of tissue selectivity, RAD 140 was synthesized to copy the muscle-building and strength-enhancing attributes of steroids, however with restricted hostile results. Nevertheless, in observe, we observe RAD 140 replicating the toxicity of some anabolic steroids, resembling Anavar or Primobolan.

RAD 140 surfaced in 2010 after being formulated by a US biotechnology firm, Radius Well being. There’s restricted scientific analysis concerning RAD 140’s results, notably on people over the long run.

RAD 140 is taken into account one of many stronger SARMs, possessing superior anabolic results to testosterone propionate in animal trials. In scientific settings, monkeys skilled a ten% improve in lean physique mass over 28 days on RAD 140 [1].

Much like anabolic steroids, RAD 140 induces lipolysis and will increase muscular energy on account of its excessive affinity when binding to androgen receptors.

Disclosure: We don’t settle for any type of promoting on Inside Bodybuilding. We monetize our observe by way of physician consultations and punctiliously chosen complement suggestions, which have given our sufferers wonderful outcomes.

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Is RAD 140 Authorized?

Because of RAD 140’s current creation, it has not been accepted for human use by the FDA. Thus, testolone is barely authorized to purchase for investigational functions, particularly restricted to animal testing.

RAD 140 has additionally been banned by the World Anti-Doping Affiliation (WADA); due to this fact, skilled athletes are prohibited from utilizing it and different SARMs [2].

RAD 140 Earlier than and After Outcomes

• This Reddit person stacked RAD 140 with one other SARM, generally known as LGD-4033.
• He additionally administered MK-677, generally known as Ibutamoren.

MK-677 is also known as a SARM on account of its related anabolic results. Nevertheless, it’s technically a development hormone secretagogue (GHS).

This person skilled vital muscle development, with some will increase in visceral fats, made seen by a notable improve in abdomen hypertrophy.

Will increase in visceral fats could also be predominantly attributed to the inclusion of MK-677 on this stack, with HGH enhancers recognized for rising insulin resistance and thus inducing visceral fats storage.

This person’s outcomes, by way of muscle hypertrophy, may be thought of average—but lower than a typical first steroid cycle.

As a visible estimate, this person seems to have gained 10 kilos (4.5 kg) of lean mass.

In animal trials, RAD 140 has produced vital will increase in muscle hypertrophy; nonetheless, in people, we see a milder impact.

Human trials have in contrast the anabolic results of testosterone enanthate versus SARMs. Researchers discovered that SARMs added 1-1.5 kg of lean mass to individuals over 4-6 weeks, whereas testosterone enanthate added 5-7 kg of lean mass [3].

RAD 140-Solely Cycle: Earlier than and After

This Reddit person’s cycle:

• He skilled modest enhancements in muscularity, albeit with a rise in subcutaneous physique fats.
• He gained 5 lb (2.3 kg) in weight, with a few of this being within the type of adipose tissue, on account of 12 weeks of consuming in a modest calorie surplus.

Compared to the primary RAD 140 earlier than and after transformation, this person has not gained a notable quantity of visceral fats, indicating that the opposite person’s improve in intestine dimension was MK-677-related.

Some may hypothesize that this person’s RAD 140 (Testolone) is probably not reliable or diluted on account of a scarcity of outcomes. Nevertheless, this person’s supply was verified to be a trusted producer.

RAD 140 Earlier than and After: 8-Week Cycle

• The above Reddit person administered lower than 10 mg/day of RAD 140 for almost all of his 8-week cycle, demonstrating that optimum outcomes can nonetheless be skilled at a low dosage.
• This person skilled vital fats loss regardless of claiming to eat in a calorie surplus. He’s displaying enhanced muscle hardness, definition, and thickness.

Regardless of gaining 10 kilos on the scales, he personally said that RAD 140 was not price it for him. This was as a result of his outcomes had been “unsubstantial,” and he skilled some hair loss.

This person’s expertise signifies that low dosages of RAD 140 could improve the reward-to-risk ratio, with him gaining 10 kilos and shedding a noticeable quantity of subcutaneous fats concurrently. Nevertheless, people prone to male sample baldness could expertise some shedding on RAD 140.

RAD 140 Dosage

RAD 140 will not be a pharmaceutically produced compound on account of a scarcity of FDA approval. Thus, there aren’t any dosage tips.

Nevertheless, we see males generally take 10-20 mg/day for 6-12 weeks to boost physique composition.

What’s a Customary RAD 140 Cycle for Males?

Girls generally take 5-10 mg/day for the same length, enabling them to expertise the advantages of RAD 140 however with none virilizing results.

What’s a Customary Feminine RAD 140 Cycle for Females?

RAD 140 sometimes is available in 10 mg capsules or a ten mg/mL liquid resolution.

What Are the Facet Results of RAD 140?

In animal research, RAD 140 has been proven to be much less poisonous than testosterone alternative remedy when administered to rats [4].

Nevertheless, in people, there seems to be a unique development, with RAD 140 demonstrating harsher unwanted effects in some customers. Dr. Nicholas Downey says that present analysis signifies that RAD 140 causes “liver points” at 50 mg/day. He additionally notes that RAD 140 is “fairly suppressive,” however the extent of this impact is unknown on account of a scarcity of human research.

Liver Toxicity

There’s present analysis indicating RAD 140’s capacity to trigger hepatocellular-cholestatic liver harm.

A 49-year-old man had taken RAD 140 repeatedly for 4 weeks [5], with intermittent use afterward. He administered RAD 140 together with an antidepressant (venlafaxine) that he had beforehand been taking for 11 months.

The person’s alcohol consumption was insignificant. Subsequently, the mixture of hepatotoxic antidepressants and SARMs could also be a deleterious mixture.

The person within the second RAD 140 before-and-after image additionally reported excessively raised alanine transaminase (ALT) and aspartate aminotransferase (AST) enzymes, demonstrating liver stress.

Dr. Thomas O’Connor, in his expertise of analyzing over 2,000 sufferers on SARMs over a decade, has likened SARMs to taking 50 mg/day of Anavar.

Dr. Ankit Batra additionally affirms that in scientific research, the hepatic issues of RAD 140 “may be just like anabolic steroids,” regardless of ALT and AST enzymes generally normalizing post-cycle.

RAD 140’s route of entry, being an oral product, is the principle explanation for hepatic stress.

This is because of it having to bypass the liver upon getting into the bloodstream, just like C-17 alpha-alkylated steroids, inflicting hepatotoxicity.

Blood Stress

We have now discovered that RAD 140, in addition to different SARMs, has a dose-dependent impact on ldl cholesterol [6], rising the chance of:

1. Atherosclerosis
2. Myocardial infarction

The second person who revealed his before-and-after transformation reported a major rise in blood stress.

That is probably on account of SARMs passing by way of the liver, which stimulates the hepatic lipase enzyme, inflicting HDL levels of cholesterol to lower. HDL ldl cholesterol is helpful to coronary heart well being, with excessive ranges lowering arterial plaque [7].

One other potential contributing issue to undesirable blood lipids could also be RAD 140’s lack of aromatization. In distinction, a number of anabolic steroids convert to estrogen, inflicting much less vital shifts in levels of cholesterol. It is because estrogen has a optimistic impact on HDL ranges, so inhibiting this conversion will not be optimum for cardiovascular well being.

Testosterone Suppression

RAD 140’s aggressive binding impact with the androgen receptor can suppress testosterone ranges, just like anabolic steroids.

The extent of such suppression on SARMs has not but been established. Nevertheless, our anecdotal knowledge suggests it’s vital. The second person within the before-and-after transformation administered 17 mg/day of RAD 140 for 12 weeks and skilled a notable decline in testosterone ranges, dropping from 750 to 193 ng/dL.

Thus, we’ve got discovered that scientific hypogonadism is feasible with RAD 140 by way of harm to the hypothalamic-pituitary-testicular axis (HPTA), doubtlessly impacting customers’ long-term fertility.

All SARMs seem to have a suppressive impact on endogenous testosterone. Nevertheless, RAD 140’s influence appears to be extra pronounced than different SARMs on account of it being a stronger compound.

Gynecomastia and Water Retention

Though RAD 140 doesn’t aromatize, it will possibly nonetheless elevate estrogen ranges by way of a unique pathway. When SARMs are administered, they start to compete with a person’s pure testosterone for binding to the androgen receptor. SARMs win this battle on account of their superior binding affinity, leaving extra free testosterone to transform to estrogen or dihydrotestosterone (DHT), consequently elevating each of those hormones.

Elevated ranges of estrogen may cause:

• Water retention
• Bloating
• Gynecomastia

Dr. Michael Moeller states that he has overseen male sufferers lactating from SARM use, together with RAD 140. Thus, possessing a light aromatase inhibitor (AI) when commencing a RAD 140 cycle may be advantageous.

Androsta-3,5-diene-7,17-dione, in any other case known as arimistane, is a light AI that may be utilized to inhibit estrogenic unwanted effects.

In our expertise, stronger AIs are prone to be excessively harsh for a SARM cycle, resembling:

• Letrozole
• Aromasin
• Anastrozole

The above AIs could trigger a hormonal imbalance, inflicting an estrogen deficiency. Potent AIs are extra appropriate for anabolic steroid cycles, the place estrogen ranges rise significantly.

Hair Loss and Prostate Enlargement

It was thought that RAD 140 could also be helpful for benign prostatic hyperplasia on account of its profitable tissue selectivity, inflicting prostate shrinkage in animal analysis. In rats, RAD 140 demonstrated low ranges of androgenicity. The rats required a 60-times greater dosage to copy the prostatic hypertrophy of testosterone [8].

Nevertheless, we’ve got had RAD 140 customers nonetheless expertise bouts of hair loss. This can be attributed to pure testosterone changing to DHT, with the previous not binding to androgen receptors.

Increased DHT ranges will trigger elevated irritation and hair miniaturization on the scalp.

If customers make the most of RAD 140 for short-term use, such hair loss could reverse when hormones regulate again to regular post-cycle. Nevertheless, long-term use and sustained excessive ranges of DHT improve the chance of androgenetic alopecia.

Elevated sebum manufacturing can also be potential, inflicting delicate customers to doubtlessly expertise zits vulgaris.

In idea, RAD 140’s tissue selectivity ought to stop any androgenic unwanted effects, that are portrayed in animal analysis. Nevertheless, its oblique influence on pure testosterone changing to DHT could also be problematic for human customers.

RAD 140 PCT

RAD 140 suppresses testosterone by way of the decreasing of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), a consequence of its binding affinity to androgen receptors.

Some RAD 140 customers test their testosterone ranges post-cycle, with the information signifying notable suppression, inflicting them to endure post-cycle remedy (PCT).

Customers can start PCT 12 days after ending a RAD 140 cycle, primarily based on its half-life of 60 hours. The elimination time is the half-life multiplied by 5.5.

Usually, we might prescribe Clomid or Nolvadex for PCT, with the latter being the stronger medicine for restoring endogenous testosterone.

Clomid could also be enough for post-cycle remedy if conducting a RAD 140-only cycle. Nevertheless, Nolvadex is prone to be extra optimum if stacking RAD 140 with different SARMs.

When it comes to the dosage and length of a RAD 140 PCT protocol, beneath are a few pattern cycles.

What’s the Half-Lifetime of RAD 140?

Primarily based on pharmacokinetic samples, RAD 140’s half-life is 60 hours [9]. Nevertheless, each day dosing stays a standard protocol amongst customers, who initially estimated its half-life to be roughly 20 hours.

RAD 140 vs. LGD-4033: How Do They Evaluate?

LGD-4033, or Ligandrol, is the stronger SARM per milligram. We have now discovered that dosages of solely 2-10 mg are essential to see notable outcomes from LGD-4033. RAD 140’s dosage is usually 10-20 mg.

RAD 140 appears to be a superior SARM in regard to elevated pumps and subcutaneous fats loss.

Thus, by way of aesthetics, RAD 140 could also be thought of extra optimum. LGD-4033 causes extra water retention; due to this fact, it is probably not advantageous for customers looking for a lean physique and most muscle definition.

A portion of the fats loss related to RAD 140 could also be oblique, on account of its urge for food suppressant results, that are superior to LGD-4033’s [10].

When it comes to muscle hypertrophy and energy, LGD-4033 and RAD 140 are related in efficiency.

We discovered that RAD 140 has a stronger muscle-hardening impact, presumably on account of estrogen ranges rising much less [11] and thus reducing water retention.

RAD 140 is prone to produce extra outstanding outcomes by way of muscular endurance, benefiting those that carry out excessive numbers of repetitions or have a coaching schedule that includes common cardiovascular coaching.

In our expertise, customers report greater power ranges on RAD 140 than LGD-4033.

LGD-4033, nonetheless, is understood to extend libido greater than RAD 140 on-cycle.

Worth supply: Sports activities Know-how Labs

What Can RAD 140 Be Stacked With?

RAD 140 can theoretically be cycled with any SARM. Such stacking enhances muscular energy, hypertrophy, and fats loss. Nevertheless, using a number of SARMs concurrently may also exacerbate unwanted effects.

Novices sometimes full a RAD 140-only cycle initially to turn into accustomed to the drug. As a person beneficial properties expertise, a stronger stack is often utilized, resembling RAD 140 and LGD-4033, for added mass and energy outcomes when bulking.

When it comes to dosages, a RAD 140 and LGD-4033 stack can look as follows:

Nevertheless, given the early indications of RAD 140’s hepatotoxic results on people [12] and its detrimental results on blood lipids, it is probably not clever to stack it with additional non-steroidal SARMs till it’s higher understood.

RAD 140 Critiques

Researchers in our personal Fb group have shared their RAD 140 opinions and experiences beneath.

RAD 140 is much stronger than LGD, an important efficiency SARM.

RAD has too many unwanted effects for my style; in the event you get to RAD, you may as nicely run correct AAS, I feel.

RAD 140 is unimaginable. I simply hit the 1,000-pound membership at 52 years outdated with a physique weight of 158 kilos.

I ran my first 12-week cycle of RAD 140 six months in the past with no unwanted effects or testosterone suppression that I may discover.

First day of week 6 on RAD 140. Zero sides. Going nice. 12.5 mg per day is all you want. Staying lean however including muscle and energy in all lifts. I added about 300 energy a day over the previous 2 weeks to get my protein even greater. My arms are extraordinarily vascular. Find it irresistible!

RAD 140 is my favourite. However for some motive, I at all times get the night time sweats in direction of the tip of the cycle. Proper now it’s fairly unhealthy. I’ll be fortunate to get 5-6 hours of sleep an evening as a result of I’ll get up fully drenched. And that’s not regular for me. Additionally, I don’t know for a undeniable fact that that’s what’s inflicting it, however they appear to go hand in hand for me.

Continuously Requested Questions

Are There Particular Well being Circumstances That Would Contraindicate the Use of RAD 140?

Sure, we’ve got noticed that the well being of hypertensive people has deteriorated on account of the usage of RAD 140, which is attributed to adjustments in ldl cholesterol. One in all our sufferers was affected by hypertension previous to their appointment with us. After stacking RAD 140 with LGD 4033 for an eight-week cycle, our clinic identified him with atherosclerosis.

Moreover, one among our sufferers developed peliosis hepatis after supplementing with 20 mg of RAD 140 per day for 12 weeks together with monoamine oxidase inhibitors.

Can Customers Drink Alcohol on RAD 140?

Our liver perform exams have decided that RAD 140 reveals hepatotoxic results. Subsequently, combining RAD 140 with alcohol throughout a cycle will increase the chance of hepatic harm.

What’s the Optimum Food plan When Supplementing With RAD 140?

In our expertise, customers generally administer RAD 140 for bulking functions. Thus, primarily based on this goal, consuming energy with a surplus of 500 can improve anabolism.

If RAD 140 is utilized for slicing functions, we’ve got discovered a calorie deficit of 500 to be efficacious in enhancing fats loss whereas sustaining muscle hypertrophy.

Are There Any Dietary supplements That Can Assist Scale back Toxicity on RAD 140?

Sure, we’ve got discovered tauroursodeoxycholic acid to be advantageous in lowering AST and ALT ranges throughout a RAD 140 cycle.

Moreover, our sufferers will generally complement with 3 grams/day of fish oil. Consequently, we’ve got recorded a mean 4.5 mmHg discount of their systolic and diastolic blood stress readings. Medical analysis additionally displays this lowered cardiovascular danger from fish oil, though the outcomes differ relying on the dose [13].

Can RAD 140 Trigger Bloating?

Some customers can expertise bloating from RAD 140, and others don’t. In our expertise, decreasing sodium consumption has been profitable in assuaging this hostile impact. After modifying their food regimen on this method, our sufferers have misplaced as much as six kilos of water weight throughout a RAD 140 cycle.

RAD 140 Execs and Cons

Execs:

• Enhanced muscle hypertrophy
• Vital improve in muscular energy
• Fats loss

Cons:

• Smaller will increase in fat-free mass in comparison with anabolic steroids
• Could improve ldl cholesterol
• Decreases endogenous testosterone
• Hepatotoxic results

Abstract

RAD 140 shows anabolic traits which may be helpful to these looking for enhancements in muscle hypertrophy and energy.

Nevertheless, there look like anabolic steroid-like dangers related to RAD 140, notably regarding liver toxicity and cardiovascular pressure.

Such deteriorations in well being are evident in a number of human trials and correlate with Dr. Thomas O’Connor’s expertise of treating men and women on RAD 140 for a decade.

With cardiotoxicity and hepatotoxicity results occurring in some customers, mixed with modest outcomes concerning muscular hypertrophy, RAD 140 could also be much less optimum than some anabolic steroids, resembling:

1. Testosterone
2. Anavar
3. Deca Durabolin

What’s Dr. O’Connor’s Expertise with RAD 140?

Dr. O’Connor believes SARMs, resembling RAD 140, are “doubtlessly extra harmful than anabolic steroids,” following common evaluation of over 2,000 sufferers’ labs. However, additional scientific analysis on RAD 140 is required to totally perceive its results, with sure researchers observing optimistic adjustments in physique composition with none discernible issues.

Co Authors :

For TRT inquiries, please contact Dr. O’Connor by way of the Anabolic Doc app.

During the last 20 years, Dr. O’Connor has efficiently handled hundreds of males who’ve taken anabolic steroids, SARMs, and different PEDs, giving him first-hand expertise of their results. Board-certified MD since 2005.

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